Care From Chiropractor In Cambridge ON Helps Locals Get Carpal Tunnel Syndrome Relief

By Clinton Arnhold

Non-invasive and natural options can be employed for managing various health problems. Professionals who practice in alternative medicine, such as chiropractic care, strive to encourage healing in patients through this type of approach. Carpal tunnel syndrome effects many people around the world, causing uncomfortable and painful symptoms. Those who seek relief for this and other ailments might look into the services made available through a top Cambridge ON chiropractor.

This syndrome may be present when the median nerve is squeezed or pressed at the wrist. This nerve runs along the forearm and into the palm of the hand. It controls the sensations and impulses to the hand.

The carpal tunnel is a rigid and narrow passage of bones and ligaments that is located at the base of the hand. This is where the tendons and median nerve are located. Sometimes irritated tendons or swelling can narrow the tunnel, which causes the nerve inside to become compressed. This results in weakness, pain and numbness in the wrist and hand. Sometimes this radiates through the arm.

A combination of factors can lead to this condition. Furthermore, many symptoms are associated with it. Each situation is different. It will be a priority for doctors to do tests to determine that patients do have this ailment before care is given.

Care needs to be given promptly. The underlying cause for this problem, such as arthritis or diabetes, must be managed as a first step in this process. Doctors are expected to encourage taking a few weeks off to rest. This is when patients should limit any actions that make the symptoms worse. Wrist immobilization is effective at preventing additional damage that might come about from twisting and other movements. Applying ice to the affected area can reduce any swelling.

Chiropractic doctors want to use effective but gentle solutions on patients. They consider surgery only in dire situations. Non-surgical procedures that may be employed instead: natural supplements or medications, acupuncture and other alternative therapies, and exercise. Certain strengthening and stretching routines can be beneficial, if done under the supervision of professionals.

About the Author:

Chiropractic care alleviates wrist and hand pain safely and effectively. Get more info about a reliable Cambridge ON chiropractor at http://www.wilsonhealth.ca now.

Tension Headache Relief From Lancaster Chiropractic Professionals

By Michael Cabunoc

Headaches are a problem for people all around the world. This can be brought on by a number of causes and is remedied through many different solutions. A tension headache or tension-type headache is considered the most common kind of primary headache. People looking for relief from this might be interested in the services available through Lancaster chiropractic facilities.

Pain can radiate to other areas of the body. In fact, many people who experience these aches feel it the most in the eyes, muscles, neck and back of their head. This type of tension ache makes up almost all of the headaches experienced in people. Over-the-counter drugs can be used to offer relief. However, some might prefer solutions that are more natural.

Chiropractic care is a form of alternative medicine that can benefit people who suffer from acute or chronic headaches that vary in degree. Tension-type headaches are often known for the constant pressure they create in the head. It may feel as if the head is being tightly squeezed. Pain may range from very minor to moderate and sometimes severe.

There are certain things associated with these kind of headaches: eyestrain, irregular meal times or hunger, uncomfortable or bad posture, sleep deprivation and stress. Chiropractic doctors will perform tests to determine the condition of a patient and potential causes for their status. They will then use this information to offer the best solutions for patients.

Sometimes changes in diet and lifestyle are enough to reduce or eliminate chronic headaches. These professionals may also utilize various natural or non-invasive procedures. These can be effective for improving posture and reduce physical and mental stress levels.

Care results will differ by person and other factors. If this condition is not eliminated or relieved through these alternative medicine solutions, patients are urged to seek further testing and care. It is essential that research is done when seeking out the best practitioners available in an area.

About the Author:

You can get safe and effective tension headache and neck pain relief through chiropractic care. Get more information about an experienced Lancaster chiropractic doctor at http://www.buckeyechiro.com now.

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Getting More Fit While Staying Away From The Gym

By Dolly Nichols

If you are a gym member or have been one in the past, you no doubt realize how beneficial it can be to your health. These days, almost all gyms have a variety exercise equipment making them a very attractive option for your fitness needs. Nonetheless, for many people, this is not always an option because of the expense involved or their location might make it difficult to use them regularly. Even if going to the gym doesn't work for you, there are a lot of other things you can do to get fit, In this article, we will talk about ways to start exercising regardless of your situation.

Wherever you happen to be, a quick way to get started is by running. The only real investment is the gear you will wear particularly your running shoes because they are essential to avoid injury or putting stress on your joints. It is now an everyday sight for us to see men and women of all abilities jogging around our roads and there are ways to make it more pleasurable for yourself. The first thing you must do is come up with some measurable goals regarding how far and how long you would like to run. If you can alter the roads and places you go on your runs, this can make it more interesting and keep you motivated. If you enjoy others with you, then you can always buddy up with a friend or sign up for a local runners group.

Gyms are typically well stocked with all types of resistance training equipment. This should not stop you from doing strength training in your own home as this is perfectly possible. If you have lots of space and money is not an issue, consider purchasing your own multi gym and install it in your home. But remember that you can get going with merely a simple set of hand weights. There are magazines and books from your local library that can guide you on what to do if you are uncertain.

A major trend today is to learn how to exercise online with the help of ebooks and videos you can view on your laptop. This can be very cost-effective because these are usually produced by expert trainers and it is like having them in your own home to help you. If you don't have the money to hire a personal trainer, this is the way to get it done. You may have used exercise videos or DVDs in the past but a recent development is using a game console to be fit. For instance, the Wii Fit game has become an extremely popular way for the entire family to become fit whilst having loads of fun. When you use this system, you get to play and get fit at the same time.

Now that you are aware it isn't hard to become fit without an expensive gym membership, it's time to get started.

About the Author:

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Menu Part 10 Retinal Reports from the 2007 AAO Meeting

During the 2007 American Academy of Ophthalmology (AAO) Meeting, and the Subspecialty Days preceding it, especially Retina 2007, I received briefs about the meetings from both Ophthalmology Times and Ocular Surgery News. Using these briefs, I was able to prepare comprehensive writeups of both the two-day Retina 2007 presentations and retinal highlights from the opening day of the main meeting. These writeups were presented in a series of three reports:

1. Retina 2007 Subspecialty Meeting Presentations – Day One

Highlights included:

Updates:

● 2-Year results of the PrONTO Study (intravitreal injections of Lucentis with OCT diagnoses for guided further treatment);

● ANCHOR Update – Lucentis vs. PDT with Visudyne;

● Avastin vs. Lucentis – A discussion of the economic and moral dilemma of using approved Lucentis vs. off-label Avastin;

● Avastin’s Impact – Despite lack of clinical data;


New Treatments for AMD:

● VEGF Trap – discussions of the CLEAR-IT AMD 1 and CLEAR-It AMD 2 trials;

● Topical Therapies – discussions of various topical treatments

- TargeGen’s 801 kinase inhibitor
- CoMentis’ ATG2
- Ocucure’s OC-10X
- Othera’s OT-551
- Glaxo-Smith-Kline’s Pazopanib

● New Developments in posterior segment drug delivery – a discussion of potetial solid implants, such as Retisert and Vitrasert from Bausch & Lomb, and a subretinal implant system from SurModics called I-vation.

And, finally, an interview with Dr. Judah Folkman, the father of anti-angiogenic agents, and the keynote speaker for the opening session of the AAO Meeting.


2. Retina 2007 Subspecialty Meeting Presentations – Day Two

Highlights included:

● A discussion of Dr. Susan Desmond-Hellmann’s (Genentech’s President, Product Development) presentation to the Retina 2007 assembly and her Q&A session;

● Sub-Retinal Implants for treating retinitis pigmentosa;

● Retinopathy of Prematurity – Anti-VEGF therapy is on the horizon;

● Spectral Domain Optical Coherence Tomography advances; and,

● New Non-Thermal Laser for Retinal Treatment – a brief discussion of the Ellex 2RT Therapy.


3. More Retinal Treatment News from the 2007 AAO – Day Three

● More from Retina 2007
- A Comparison of Lucentis vs. Avastin;
- An Update on the CATT Study;
- Additional information about the Ellex 2RT laser treatment.

● Retinal-related Information from the Main AAO Meeting
- The keynote address by Dr. Judah Folkman;
- An overview of intravitreal drugs for treating diabetic retinopathy; and,
- Intravitreal therapy for vein-occlusive disease.

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Health Tips From Chiropractic Concord NC

By Deanne Shepard

Chiropractors focus on structural balance and biomechanical function without pain, discomfort, and general restrictions. All methods are geared toward meeting individual needs for a healthy recovery from injuries, improved athletic performance, management of chronic conditions, and overall wellness. With reliance on tips from chiropractic Concord NC residents can work towards a state of well-being for natural and long term care.

The practice of chiropractic will deliver heightened support to work towards a balanced and fully functional spinal column. For those who are unaware of the impact that a misaligned spine can have on operation, it is important to identify symptoms and to seek alternative therapy. The body should experience heightened levels of support to assist in working towards a state of balance and to correct impacted nerves.

For those who suffer from severe back ache, in most instances it can be attributed to the poor structural alignment of the spinal column. This includes the impingement of nerves when the vertebrae are moved out of its original position because of injuries, obesity or bad posture making it difficult to move normally and discomfort may result. The most common complaint in the chiropractic office is back pain that can be better managed if structural problems are detected.

For those who wish to buffer against the symptoms of an imbalanced spine, it is important to rely on a number of healthy steps that can be taken for wellness. The participation in suitable exercises aimed at delivering core strength and fuller functionality can ease the strain and limitations placed on the tissues. There are many alternative therapeutic techniques available for suitable operation.

Methods such as sitting and standing may seem simple enough, but slouching can place pressure on the vertebrae. If you are sitting at a desk, place both feet firmly on the ground and do not bend the shoulders forward. The aim is to keep the spine straight as this can decrease a significant amount of strain placed on the ability to operate in a normal manner.

The spine needs to remain supported when it comes to lifting heavy objects. Do not engage in any form of twisting movement and squat to pick heavier objects off the ground as it minimizes spinal pressure. If the item is of a substantial weight, do not force yourself to life it, but try to push it using your legs.

Regular exercises should be performed that will aid in building the necessary muscle strength and flexibility. When it comes to creating the necessary workouts, it is important that individual needs are met and that a healthy weight is maintained that will minimize the experience of pressure and strain that are experienced on the spinal column. All medical conditions should be discussed with a practitioner before moving forward with particular activities.

For those interested in achieving a state of health and wellness, it is important to support the body with the correct forms of intervention. The experience and professional approach offered by a chiropractor can aid in facilitating an optimum state of spinal health. All restrictions will be examined and natural methods of support advised for healthy operation.

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Read more about More Reasons To Seek Chiropractic Concord NC.

Reap Numerous Benefits From Herbal Tea For Weight Loss

By Diane Fisher

There are numerous methods available when it comes to lowering your body mass. This being said, some of these techniques work better than others. This can be for different reasons. In terms of herbal tea for weight loss, this option offers you numerous benefits. It is easy to add the drink into your routine and you can consume it during the day or night based on your schedule. It's possible to choose from a variety of kinds and add ingredients to change the taste as preferred. Decaffeinated forms of the beverage may help to hydrate the body which is important to this process. Such benefits and others obtained from this route can mean that this is the solution you need.

No matter how much weight you want to lose, there are many methods of doing so. These routes range from short term diets to long-term lifestyle changes. Naturally, eating a well-balanced healthy diet is recommended. However, sometimes you may require a little more help than this.

It's possible to choose from various kinds of tea for this purpose. The options have a variety of flavors. You can add some low-calorie sweetener or other ingredients to change the taste more suitable for your preference. Depending on the product, there may be recommendations on what to add to obtain certain flavors.

While being able to change the flavor is one benefit of this solution, there are others to consider. One such advantage is the ease of use. Tea is something you can add to the daily routine without a hassle. You only need a kettle or microwave to make the beverage. You may make it at home or at work. If you prefer, you can also take the drink with you wherever you go in an insulated cup.

In most cases, you can consume the tea several times a day. This is especially true if you choose a decaffeinated variety. You are recommended to choose a type without the caffeine if you are sensitive to this stimulant.

The decaffeinated options may be considered as a way to keep hydrated as well. Everyone needs a certain level of water in their body. Such beverages are mostly water. Without the caffeine to dehydrate the body, the water stays longer within the bodily systems. This is important to staying healthy and to functioning properly.

When you use these beverages to help you lose weight, there may be some instructions to follow. The directions will normally be on the package. These instructions are there to help you get the best results.

You may find various methods of losing weight but some are better than others. Herbal teas have a lot to offer in terms of their advantages. These drinks are easy to add to your routine and they can usually be consumed several times a day, depending on the type you choose. There are ways of altering the taste based on your preferences. With these benefits and more, these beverages can be the solution you need.

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If you are looking for the facts about herbal tea for weight loss, pay a visit to our web pages online today. Additional details are available at http://vi-taltea.com now.

Take Your Time Results from Yoga Practice

by Nina

Horses Grazing by Brad Gibson

It's a running joke in our family that when Brad gets impatient with me—because I often do various household tasks a bit slower than he does—he says to me, "Take your time!" He swears that Bill Murray said this repeatedly in the movie Caddy Shack, but when we watched it again recently, no one actually ever uttered that line. Regardless, I always reply, "You take your time."

But many worthwhile things really do take time. For example, if you want to cook a really good meal instead of eating fast food, you need to shop for fresh ingredients and prepare everything from scratch. And if you want to turn a new acquaintance into a close friend, you need to spend a lot of time together, getting to know and trust each other. The same is true for seeing results from yoga practice. Obviously, one Downward-Facing Dog pose doesn't instantly make your arms stronger, though with regular practice, it definitely will increase your strength. And it also seems obvious that if you want to reduce your stress levels, you'll need to practice stress management regularly over a period of time.

So it was very interesting for me to hear about a recent study at the Feinberg School of Medicine, Northwestern University, that looked at the effect of exercise on insomnia. One of the findings as reported by Gretchen Reynolds in the New York Times post How Exercise Can Help Us Sleep Better was:

"After the first two months of their exercise program, the exercising volunteers (all of them women) were sleeping no better than at the start of the study. Only after four months of the program had their insomnia improved."

Yes, it took four whole months of regular exercising to bring improvements. That's quite a bit of time, don't you think? The women in this study were not practicing yoga for exercise, but it's likely that using yoga as a form of exercise to help with insomnia (something I definitely recommend) might take a similar amount of time. And it also makes sense to me that if you are practicing yoga for insomnia (see Yoga for Insomnia, Part 1) by using stress management techniques, you should also give that some time (though some people report that doing breath practices in the middle of the night produces immediate results). So be patient.

In general, the time you invest in your yoga practice—whether you are practicing for your physical health, your emotional health or both—is what brings the payoffs. After all, yoga sutra 1.14 tells us that equanimity is attained only through steady, dedicated, attentive practice:

Long, uninterrupted, alert practice is the firm foundation for restraining the fluctuations of the mind. —trans. by B.K.S. Iyengar 

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How South Charlotte NC Chiropractor Helps Alleviate Pain From Auto Accidents

By Angeleah Mae Zerna

Kids can sustain a number of injuries as the result of car accidents. This is true even if they do not break any bones or receive any lacerations or other visible wounds. This is why it is important to take your child to a South Charlotte pediatric chiropractor after these events.

Chiropractic professionals will want to know if your child has developed any subluxations of the spine. These occur when the vertebrae move or are forced out of position. This is often the case after an auto accident and it can lead to a range of uncomfortable health issues. This is often why people without visible wounds feel a tremendous amount of discomfort.

The nerves communicate with the brain across the spine. Alignment issues impede this communication. As a result, kids can experience chemical imbalances that lead to sleep loss, lower immunity, depression and mood swings. They can also experience a lot of physical pain.

When subluxations exist, some muscle groups are required to work a lot harder than normal. As the result of compensating for spinal injuries, these muscles can become strained. This in turns leads to muscle spasms, recurring headaches and even diminished mobility.

Chiropractic care for children is often a very gentle and gradual process. The primary goal is to restore good spinal alignment and overall spinal health. Chiropractors can use manual adjustments and they can also perform massage. Over time, problems such as stiffness, headaches and fatigue will gradually abate. Given that this is a very natural form of pain relief and one that can expedite the normal healing process, it is often far preferable to the use of prescription drugs for alleviating discomfort.

When swelling, pain and joint dysfunction are severe, different options in chiropractic equipment may be included in the therapy plan as well. For instance, kids can receive ultrasound therapies or even inversion table therapies. Both of these reduce pressure and pain and can alleviate inflammation.

About the Author:

Chiropractic care alleviates arm, shoulder, back and buttock pain safely and effectively. Get more info about a reliable South Charlotte pediatric chiropractor at http://www.ActiveLifeNC.com now.

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A Novel Gene Therapy Approach to Treating the Wet Form of AMD The BioFactoryTM From Avalanche Biotech

I originally contacted this company in November 2010, when they were still in “stealth mode” and weren't able to share details about what they were doing. Recently, the company got back in touch to provide an update, having announced, in December 2011, a clinical trial of their gene therapy approach to treating the wet form of AMD.

Since their approach is unique, and possibly “game changing” for the treatment of the wet form of AMD, I asked if I could prepare a writeup about the company and its technology for publication in my online Journal, and the co-founder and CEO Tom Chalberg agreed to answer my questions, as best as he could.

So, here in their own words is what Avalanche Biotech is all about.

The Company

Founded in 2006, as an outgrowth of co-founder Thomas Chalberg’s PhD work in genetics while at Stanford University (along with pioneering work with gene therapy at Prof. Elizabeth Rakoczy’s lab at the Lions Eye Institute in Perth, Australia), Avalanche Biotech is a privately held biotechnology company that develops technologies and products for sustained delivery of therapeutic proteins to the eye to treat wet age-related macular degeneration (AMD), as well as other ophthalmic disorders, such as diabetic retinopathy, retinal degeneration, and glaucoma.

The company was incubated at the Berkeley Entrepreneurship Laboratory at the UC Berkeley Haas School of Business in 2010-2011 while Tom was completing his MBA at that school. The company set up offices in San Francisco’s SOMA district, near the UCSF Mission Bay Campus, in July 2011.

The company’s lead product treats wet AMD by using the body's own cells to produce therapeutic proteins on an ongoing basis after only a single injection. The goal is effective long-term treatment of wet AMD without the burden of frequent, ongoing intra-ocular injections.

In June 2011, Avalanche Biotechnologies licensed additional intellectual property from the University of California, Berkeley, property related to novel adeno-associated virus (AAV) vectors for use with the company's proprietary BioFactory^TM drug delivery platform. A BioFactory™ is a long-term ocular drug delivery technology that secretes a therapeutic protein over years following a single eye injection. The company’s intellectual property includes access to a pipeline of next-generation vectors for non-invasive drug delivery to the retina.

In November 2011, Avalanche began a collaboration with Lions Eye Institute in Perth to commercialize AAV-based approaches, developed using the company’s proprietary BioFactory™ drug delivery platform.

The People – Founders and Management Team

Thomas W. Chalberg, PhD

Co-Founder & Chief Executive Officer

Dr. Chalberg, earned his PhD in Genetics from Stanford University where, as a Howard Hughes Medical Institute Fellow, he focused on retinal diseases and novel technologies for gene therapy. He was interested in retinal diseases, including retinal degenerations and age-related macular degeneration (AMD). During his PhD program at Stanford, he worked with Dr. Mark Blumenkranz, his committee member and a co-founder of Avalanche Biotech, on creating a sustainable solution for sustained delivery of therapeutic proteins to the retina. They were joined by Mitchell Finer PhD, a biotechnology industry expert with experience in gene therapy, and Steven Schwartz MD, an expert in retinal disease and early-stage clinical development.

Prior to joining Avalanche, Dr. Chalberg worked on the ophthalmology team at Genentech, helping to launch Lucentis (ranibizumab by injection), a novel therapeutic for age-related macular degeneration. Dr. Chalberg holds an A.B. from Harvard University, where he graduated magna cum laude and Phi Beta Kappa. He earned a PhD in Genetics from the Stanford University School of Medicine and an MBA from the UC Berkeley Haas School of Business. Tom is a member of the Board of Visionary Scientists for Hope for Vision, a non-profit charity supporting vision research.

Dr. Chalberg joined Avalanche Biotechnologies, Inc. on a full-time basis as President and Chief Executive Officer on October 11, 2010.

Mark S. Blumenkranz, MD

Co-Founder & Director

Dr. Blumenkranz is an ophthalmologist and trained vitreoretinal surgeon at the Byers Eye Institute at Stanford University, where he has served as Chairman of Ophthalmology since 1997. Prior to that, he served on the faculty of the Bascom Palmer Eye Institute in Miami, Florida, and as founder and Director of the Vitreoretinal Fellowship Program at William Beaumont Hospital in Royal Oak, Michigan – two of the top retinal training programs in the United States. His primary clinical interests center on medical and surgical treatment of vitreoretinal diseases, with a specific emphasis on macular problems. Dr. Blumenkranz was also a founding member of the Eyetech Pharmaceuticals Scientific Advisory Board and a founder or director at several Silicon Valley-based biotech startups, including Oculex Pharmaceuticals, MacuSight, Optimedica, and PEAK Surgical. Mark received his B.A. and Master of Medical Science in Biochemical Pharmacology of Brown University and M.D. degree at Brown University followed by a Residency in Ophthalmology at Stanford.

Steven D. Schwartz, MD

Co-Founder & Director

Dr. Schwartz is an ophthalmologist and trained vitreoretinal surgeon at the UCLA Jules Stein Eye Institute, where he serves as Director of the Retina Service. At UCLA, he has served as principal investigator in a number of early-stage clinical trials for retinal diseases, including the initial studies for ranibizumab (Lucentis) and novel products in gene and cell therapy. Dr. Schwartz has held various key positions at Eyetech Pharmaceuticals, and has served on a number of Scientific Advisory Boards, including Genentech, Ophthotech, Optos, and Optimedica. Steve received his B.A. from UC Berkeley and his M.D. from USC School of Medicine, followed by a Residency in Ophthalmology at UCLA and vitreoretinal fellowship at Moorefield's Eye Hospital in London.

Mitchell H. Finer, PhD

Co-Founder & Senior Consultant

Dr. Finer has over 25 years of experience in biotechnology, building and managing companies from discovery through market launch, in addition to pioneering the development of human monoclonal antibodies, and cell and gene therapies. Currently, Dr. Finer serves as a Senior Consultant to Avalanche and is the Chief Scientific Officer of bluebird bio. Previously, he served as senior vice president of development and operations for Novocell (now Viacyte), a stem cell engineering company researching treatments for diabetes and other chronic diseases. Dr. Finer has served as CEO of Intracel Holdings LLC and Genteric Inc., and as vice president of research and development for the Gencell division of Aventis Pharma (now Sanofi). He was also a founder and vice president of research for Cell Genesys Inc., and a founder of Abgenix. Mitch received a B.S. in biochemistry and molecular biology from the University of California at Berkeley and a Ph.D. in biochemistry and molecular biology from Harvard University. He completed a postdoctoral fellowship at the Whitehead Institute for Biomedical Research.

Advisory Boards

On October 1, 2010, Avalanche announced the founding members of its Scientific and Clinical Advisory Board. The Scientific Advisory Board is chaired by Dr. Elizabeth Rakoczy, Winthrop Professor of Molecular Ophthalmology at the Lions Eye Institute, University of Western Australia. Joining her is Dr. Mitchell Finer, Chief Scientific Officer of bluebird bio and a co-founder of Avalanche.

The Clinical Advisory Board will be chaired by Dr. Ian J. Constable, Founder and Professor at the Lions Eye Institute, University of Western Australia. Joining him is Dr. Mark S. Blumenkranz, Chairman of Ophthalmology at the Byers Eye Institute at Stanford, Dr. Steven D. Schwartz, Chief of the Retina Division at the UCLA Jules Stein Eye Institute, Dr. Judy Gordon, a clinical regulatory consultant with extensive experience in ophthalmology products, and Dr. Steven Butler, Consulting Senior Biostatistician.

On September 1, 2011, Avalanche announced the addition of three renowned scientific leaders in academia and industry to its Scientific Advisory Board: Dr. Jean Bennett, F.M. Kirby professor of ophthalmology at the University of Pennsylvania; Dr. Estuardo Aguilar-Cordova, CEO of Advantagene; and Dr. J. Fraser Wright, Director of the Clinical Vector Core at Children's Hospital of Philadelphia. They will join an august group of colleagues on Avalanche's Scientific and Clinical Advisory Boards.

The Technology

The Avalanche Approach

Currently, wet age-related macular degeneration is treated with frequent injections of an anti-VEGF protein directly into the vitreous of the eye, requiring frequent office visits to assess progress and for retreatment injections with the drug, as many as 8-12 retreatments per year. This creates a burden for both patients and physicians, and limits access for those who are not able to comply with frequent visits and injections.

Avalanche’s lead product is AVA-101, currently in clinical testing for the treatment of wet AMD. Following a single injection, AVA-101 creates an Ocular BioFactory^TM that continuously secretes a therapeutic protein over an extended period, avoiding the need for frequent intraocular injections of recombinant anti-VEGF protein. The therapeutic protein is a potent inhibitor of vascular endothelial growth factor (VEGF), a clinically validated target in wet AMD. Drug delivery technology for the Ocular Biofactory™ has been pioneered under the leadership of Elizabeth P. Rakoczy, Winthrop, Professor of Molecular Ophthalmology at the Lions Eye Institute. As of mid-December 2011, Phase I/II clinical trials are in progress to evaluate safety and efficacy of a single subretinal injection of AVA-101 into eyes of patients with exudative age-related macular degeneration (wet AMD).

The Ocular BioFactory^TM

Avalanche has developed a proprietary drug delivery system which uses the body's own cells to produce therapeutic protein on an ongoing basis after only a single injection This, in effect, creates a "BioFactory^TM" in the patient's eye to treat wet AMD.

The Ocular BioFactory^TM

How it Works

Avalanche delivers its therapeutic treatments through the use of a vector made from a small biological nanoparticle called Adeno-Associated Virus (AAV). Humans are commonly exposed to AAV without any known safety issues or association with disease. AAV-based therapies are in development for a wide range of diseases including heart failure, Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS), among others, along with a litany of retinal diseases in addition to the treatment of AMD.

To create a safe therapeutic vector, viral genes are removed from AAV and replaced with specific genes encoding a therapeutic protein that specifically treats AMD. AAV can infect a variety of retinal cell types and remain stable, resulting in long-term therapeutic protein expression in a variety of retinal cell types. In clinical studies, AAV appears safe and well-tolerated when injected into the retina.

The Avalanche Difference

As opposed to the current standard of care, which is effective for a short period of time, the Ocular BioFactory^TM continues to express therapeutic protein, gathering momentum and reaching peak expression after 4-6 weeks. At that point, the treatment continues to be maintained on an ongoing basis. The result is a continuous, steady-state level of therapeutic protein, which eliminates the need for frequent re-injections. Based on preclinical studies, the therapeutic effect will be maintained for at least 18 months and has the potential to last for several years following treatment from a single injection.(1)

Collaborations

Avalanche collaborates with leading academic institutions and pharmaceutical companies to develop and market its drug delivery platforms. We are looking for strategic partnerships with companies focused on ophthalmology and drug delivery for eye disease.

Our Partners Include:

Lions Eye Institute

In 1975 the Lions Save-Sight Foundation (LSSF) established the Lions Chair in Ophthalmology at the University of Western Australia (UWA). Professor Ian Constable AO was appointed to this position and subsequently established the Lions Eye Institute (LEI). As LEI's inaugural Managing Director, Professor Constable spearheaded its efforts to eradicate blindness worldwide. LEI conducts first class scientific research into blindness and incorporates one of Australia's largest ophthalmic practices. The Institute also houses the Lions Eye Bank and the LSSF.

As noted above, Avalanche announced its collaboration with the Lions Eye Institute in November 2011, and its first human clinical trial is being undertaken at the institution.

Merck Sharp & Dohme Corporation

Merck (known as MSD outside the United States and Canada) is a global healthcare leader working to help the world be well. Through prescription medicines, vaccines, biologic therapies, and consumer care and animal health products, Merck works with customers and operates in more than 140 countries to deliver innovative health solutions.

The therapeutic protein used in the Ocular BioFactory^TM is exclusively licensed by Avalanche from Merck Sharp & Dohme Corp, formerly Merck & Co., Inc.

The Clinical Trial

The initial clinical trial, Safety and Efficacy Study of rAAV.sFlt-1 in Patients With Exudative Age-Related Macular Degeneration (AMD), NCT01494805, is currently recruiting participants at the Lions Eye Institute, in Perth, Western Australia, and was established on December 14, 2011.

It is a Phase I/II controlled dose-escalating trial to establish baseline safety and efficacy of a single subretinal injection of AVA-101 (rAAV.sFlt-1) into eyes of patients with exudative age-related macular degeneration.

The study will involve 24 patients aged 65 or above who have wet AMD. The patients will be radomized to receive one of two doses of the agent (16 patients) or assigned to the control group (8 patients). Patients in all three groups will be eligible for rescue therapy with ranibizumb (Lucentis). The study is estimated to be completed in three years (December 2014), with a primary completion date of December 2012 (i.e., final data collection for primary outcome measurement). (For more information, please follow the NCT hyperlink above.)

The Future

The company is involved in researching several other therapeutic proteins for the following indications, according to the Clinical Trials and Milestones graphic shown below:

AVA--201 – is in research for the treatment of specific cells in the retina, including possible treatment for rare genetic diseases.

AVA--301 – is in research for the treatment of diseases associated with photoreceptor cells.

Editor’s Comments – As I noted in my introduction, if this approach is successful, it could result in a “game change” in the way wet AMD is treated. Instead of multiple injections to gain control of neovascularization, one injection at the first signs of neovascularization could stop it dead in its tracks and the effect could last, potentially, for several years.

In addition, it is conceivable that patients at risk of developing wet AMD could receive a therapeutic injection of AVA-101 to prevent the occurrence of wet AMD! This would be a definite paradigm shift in the treatment of AMD.

With the human clinical testing now underway, we should have an indication of initial results with this unique approach within about a year.

Stay tuned!

For more on the technical aspects of the company’s technology, please see reference 2.

References:

1. AAV2 Gene Therapy Readministration in Three Adults with Congenital Blindness ; Bennett, J., Ashtari, M., Wellman, J., Marshall, K. A., Cyckowski, L. L., Chung, D. C., McCague, S., et al.; (2012). Science translational medicine, 4(120), 120ra15–120ra15. doi:10.1126/scitranslmed.3002865

2. Preclinical safety evaluation of subretinal AAV2.sFlt-1 in non-human primates; Lai, et al, Gene Therapy, (10 November 2011) | doi:10.1038/gt.2011.169

Sports Injury Care With Help From Dallas GA Chiropractor

By Derick Scartel

It is important to keep the body healthy. This means regular exercise and physical activity. Athletes, both amateurs and professionals, know that while their sports activity can keep them fit and well, they are at risk of developing injuries. When the body suffers from a physical injury, it can compromise the overall well-being of an individual. This is why medical care is so important. Dallas GA chiropractor refers to professionals who can offer injury care and other health solutions to locals.

Chiropractic care serves as an alternative medicine. It applies strategies that are less invasive and more organic than most other medical practices. The solutions used in this field of medicine are applicable to numerous ailments, including injuries caused by sports. The driving force behind the medicine is that idea that the body can naturally heal itself.

People are encouraged to do research to find the best professionals in their region. Consider reviews and ratings of former patients, insurance plans accepted, available services and potential costs. It is essential that patients find a doctor they are comfortable with. One whom they can express their questions and concerns to.

Athletes are often interested in this type of medicine because of its more natural approach. Many of these patients are interested in being active and playing sports again, after they have healed. They are skeptical of major surgeries or prescription drugs because these can come with side effects more devastating than the original injury.

Chiropractics are expected to take a more gradual approach. One of their main priorities, in the beginning, may be managing pain of patients. Many sports-related injuries will bring about pain that is uncomfortable and even debilitating. To manage this symptom, natural supplements can be used effectively.

The method of care used on a patient will vary, based on the injury and other details. Practitioners might suggest various exercises and stretches that target the injured area. Furthermore, changes to lifestyle and diet might also provide patients with improved wellness. Spinal manipulation, acupuncture, R. I. C. E. And other hands-on techniques are also known to be beneficial. Results will vary by case.

About the Author:

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Friday Fun Words of Wisdom from Chicago Cubs Yoga Teacher

by Nina

In Meet Darnell McDonald, Mental Skills Coordinator for the Chicago Cubs Darnell McDonald, mental skills coordinator for the Chicago Cubs, explained why meditation and simply being present give players a competitive advantage.

“You learn when you get to professional baseball that everyone is good. The separator is the seventh game of the World Series, the team that is able to execute under pressure, take off the autopilot button,” he says. “Everything we do, we do better in the present moment.”

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How To Ease Yourself From Neck Pain Worries

By Sarah Robinson

Body aches can cause anguish and frustration. In most cases, patients have experience delays at their daily routines and activities. Serious signs and symptoms might show in the later years as well. Pain, notwithstanding of its type, has always been a huge dilemma of many.

Agony might radiates from the different parts of the body that brings discomfort to anyone. Due to certain complications and for other reasons, some people are enduring the effects caused by a neck pain Conroe. This might seem a normal daily thing, but this should not be taken too lightly. Good thing that there are steps and strategies you can do to prevent the pain from coming back. Below are key tips and tricks that might come in handy one day.

Change of pillows. Most of us believe that our pillows changes our position and could in fact cause inconvenience rather than comfort sometimes. Should you are suspecting that one reason for pain to occur is because of pillows, change it. Then, see the changes and difference for yourself. If your condition persistently lingers and shows no sign of stopping, consider the next option.

Sleep on your back. Sleeping on best possible position calms and helps spine to have a comfortable rest. Since the neck and spine is somehow interconnected, this is one ideal position. Try placing pillow on every arm to takes off strain. If ever you are suffering from a serious condition, its highly advisable to talk to a doctor to address your needs.

Avoid texting too much. Looking down or texting on the phone develops an excessive strain which will sooner or later cause anguish. Over time, an increase of stress on joints affect the neck regions. Consider raising the phone higher or simply maintain an eye level view. Have some frequent breaks too. When using cellular device for hours, avoid tilting head.

Eye level computer monitor. Sit comfortably straight when facing the computer and then slowly close your eyes. After that, open them and see if your sight is focus on the middle of the computer screen or not. Laptops are different, however. Since they can be move in a downward and upward position, it might be best to use big monitors and screens for your own convenience.

Stay hydrated. Drinking lots of water hydrate your discs and give you a comfortable sleep at night. The discs are those spongy structures that mostly lie on between the vertebrae. They are made mostly of water, so being well hydrated might solve the situation. Ideally, a suggested amount which is eight glasses of water might provide you the best kind of result.

Balance your weight evenly. Carrying a heavy item on one side of body can be dangerous. Yet many fail to realize this. Aside from lightening the load of your materials, make an effort to keep your shoulders even. In that way, there might be less problem in the long run.

Perform regular neck exercise. This is practically viewed by many people as one essential solution. Stretching together with proper exercise introduce benefits someday.

About the Author:

When you are searching for the facts about neck pain Conroe residents can come to our web pages today. More details are available at http://www.lordexspineinstituteofconroe.com now.