Research in Retinal Disease The Foundation Fighting Blindness Invests 2 1 Million in Seven New Research Efforts

As I continually search the web for interesting news about new technologies for treating retinal diseases, I came across this news from the Foundation Fighting Blindness’ website  yesterday afternoon. It relates to some of the annual grants to researchers that the FFB will be funding this year. It includes better ways of looking at retinal cells (via use of the adaptive optics laser scanning ophthalmoscope) and several projects involving gene therapy, along with a couple looking at ways of, hopefully, stopping the progression of dry AMD.

The following write up is reprinted with permission of the FFB.

The Foundation Invests $2.1 Million in Seven New Research Efforts

The Foundation Fighting Blindness

August 15, 2013

The Foundation's Scientific Advisory Board (SAB) recently completed its annual grants review process, leading to the allocation of $2.1 million in funding for seven new research projects, including those for identifying new disease-causing gene mutations, developing cross-cutting gene therapies and advancing potential treatments for dry age-related macular degeneration. The three-year grants were awarded after the SAB reviewed 117 proposals submitted to the Foundation last October.

"Grants review is a rigorous, multi-step process that takes most of the year to complete," says Stephen Rose, Ph.D., chief research officer, Foundation Fighting Blindness. "Due to revenue limitations, we can only fund a fraction of the high-quality projects we'd like to fund. That makes the selection process even more challenging. We had to leave several excellent proposals on the table."

Here are brief descriptions of the new research projects:

AOSLO: Detecting Retinal Degeneration Before Vision is Lost

The adaptive optics laser scanning ophthalmoscope (AOSLO) is like a powerful microscope that enables retinal researchers to see structural changes in the retina well before vision is lost from a retinal disease. That power can enable researchers to more quickly determine if a treatment is working in a clinical trial. Austin Roorda, Ph.D., of the University of California, Berkeley, is performing studies of AOSLO to correlate changes in the retina (e.g., loss of photoreceptors) with changes in vision.

Enhancing AOSLO for Expanded Clinical Use

Like Dr. Roorda, Stephen Burns, Ph.D., of the University of Indiana, is working with AOSLO to study the correlation between retinal and vision changes. He is also making AOSLO more affordable by using newer camera technology. In addition, he's employing state-of-the-art computing technologies derived from video games to decrease image-processing times and costs. The new technology will make the imaging process more comfortable for the patient by tolerating more head and eye movement.

Figuring Out Why Severity of Vision Loss Varies for People with XLRP

Researchers have reported for many years that the severity of vision loss for people with X-linked retinitis pigmentosa (XLRP) can vary greatly, even for people within the same family. Stephen Daiger, Ph.D., of the University of Texas Health Science Center at Houston, will be looking at the role of a various biological, genetic and environmental factors in vision-loss variability for those with XLRP. The identification of a significant factor that modulates vision-loss severity - perhaps a protective protein - could lead to a potential treatment.

Finding New Genes Linked to ADRP

Researchers have identified almost two dozen genes linked to autosomal dominant retinitis pigmentosa (adRP), but many are yet to be found. Rui Chen, Ph.D., of Baylor College of Medicine, is on the hunt for those remaining adRP genes. With DNA from 118 adRP families, including 18 families with at least nine affected members, Dr. Chen is well positioned to identify additional genes linked to adRP. Finding the new genes will provide researchers with targets for treatments and cures.

Developing Neuroprotective Gene Therapies to Preserve Vision

John Ash, Ph.D., is developing gene therapies that have the potential to preserve vision in people affected by a broad range of retinal diseases. Unlike corrective gene therapies, which work only for conditions caused by a specific gene, Dr. Ash's proposed treatments are designed to keep the retina healthy independent of the underlying disease-causing gene. He also believes the proteins delivered by his treatments - PIM-1 and STAT3 - will be less likely to cause damaging inflammatory side effects than some previously investigated neuroprotective proteins.

Targeting Inflammation to Halt AMD

Thanks to previous Foundation-funded genetic studies, researchers have strong evidence that the progression of age-related macular degeneration is associated with an over-active immune system. This ultimately leads to inflammation and cell death in the retinal pigment epithelium (RPE), a layer of cells that provides critical waste and nutritional support to photoreceptors. Loss of the RPE subsequently leads to loss of photoreceptors and vision. Jayakrishna Ambati, M.D., of the University of Kentucky, is developing a gene therapy that preserves the RPE by preventing the harmful sequence of immune-system events.

Boosting Cells' Energy Supplies to Save Vision in AMD

Based on prior research, Deborah Ferrington, M.D., of the University of Minnesota, believes that mitochondrial dysfunction in the RPE plays a significant role in the development of AMD. Mitochondria are like miniature organs (organelles) within all cells that provide energy. When not working properly in retinal cells, they can lead to cell death and vision loss. Dr. Ferrington is evaluating compounds that help protect mitochondrial function in the RPE.

An Informative Piece On Lyme Disease Supplements

By Angela White

It is every ones desire to be healthy always. The unpleasant discomfort that results from being unwell makes people aim to be healthy all the time. Medical researchers and doctors have in the recently come up with supplements for different diseases that help prevent, add nutrients to the body system, speed up recovery and reduce effects of diseases such as Lyme disease. In connection to this, the following is information to help people discover more about Lyme disease supplements.

IT is transmitted through a bite by an infected tick known as the deer tick and is classified as a bacterial disease. It has common symptoms like headache, fatigue, fever and achy joints. It is a contagious disease and if detected in its early stages can be treated effectively. Supplements greatly help with the treating process of this illness as they strengthens ones body mechanism aiding for the cure.

The immune system is boosted by using supplements. Ones immunity gets low as the body tries to fight the illness once it attacks the system hence taking supplements help greatly boost the immune system. The bodys antibodies work effectively in fighting the disease when the immunity is high therefore assist in curing the Lyme.

They assist greatly in killing infections. Eliminating the infections that arise as a result of the Lyme makes it easier for the disease to be treated and completely eradicated from the body. People suffering from the illness can remain continually ill even after treating it when the infections are failed to be killed hence can cause worse effects and may take quite a while to recover.

These supplements help to speed recovery. By boosting the bodys immune system and killings the infections that result from this ailment, the recovery process is accelerated. The possibility of replication of any virus or bacteria is decreased by the supplements making it possible for quick recovery of the patients suffering from this disease.

The dangerous and harmful effects that are caused by the illness are repaired and protected by using these supplements. For instance, in the process of using antibiotics to cure Lyme, it can lead to yeast overgrowth in the intestines. They help widely to deal with this among many other effects. The disease can disturb sleep to the infected persons causing a lot of discomfort since insufficient sleep can worsen the symptoms of this ailment.

The essential and required micronutrients that are required by the body to help infected persons recover are majorly found in these supplements. The muscles, kidney, the immune system, liver ad hormones functions are improved by taking the supplements therefore accelerating the process of healing. Minimization of inflammation and detoxification is enabled through the nutrients hence hastening recovery.

In conclusion, the supplements are beneficial as they boost immune system, aid in recovery and kill infections among many other benefits. Moreover, patients suffering from this illness should ensure that they maintain a healthy diet always and exercise frequently. This will also help to fight the disease in a great way. A good diet and exercise never goes wrong.

About the Author:

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Cancer Diabetes Heart Disease can be overcome through diet

An Interview with Dr. Tom Wu N.M.D.

Cancer, Diabetes, & Heart Disease can be overcome through diet. Dr. Tom Wu’s breakthroughs with Cancer & Diabetes have earned him the “Remarkable Contribution Award” from the American Cancer Society and the “World Famous Doctor Award” from The United Nations.

Jeff :
Dr. Wu, you have helped many thousands of people use “Readily Available Foods” to help win the battle against cancer, various forms of heart disease, and even helping people with type 1 & 2 diabetes to stabilize their blood sugar naturally. You use many tools, but mostly it is about Simple Foods. Often times you give seminars to Western Doctors in Europe in groups of over 1000. Do you find that these European Western Doctors are receptive to your methods given you have achieved such phenomenal results? Is there any resistance ?

Dr. Tom Wu :
Most of the time doctors are receptive to what we are saying. We don’t force them to believe, but we show them the results we’ve been having. I tell them to try the program for 3 months and provide them a scientific presentation, which proves that all of these diseases come from the wrong food. Fried food causes blockage in the arteries, bad circulation, cholesterol, and then Heart disease. They realize these things. Instead of giving a cholesterol lowering drug, we stop them from eating greasy foods. Many of the Doctors find a good result. We use cleansing foods, which are very high in phytochemicals. These are good for cleansing out the cholesterol and homocysteine, which are the main risk factors for heart disease. Phytochemicals are nature’s cleansing agents for ridding the body of arterial plaque. They must come from the food that God has provided us within its natural state, complete with its co-factors and co-enzymes.

Jeff :
Let’s talk about helping to win the battle against Cancer. You’ve consulted a significant number of people in using “Readily Available Foods” to help win the fight against: Lung cancer, Breast cancer, and even Pancreatic cancer, which is known as being a certain death sentence. Your dietary guidelines have achieved success where most have failed. America spends over 200 Billion dollars annually on Cancer treatment and over 50 billion annually into researching a cure, but you seem to understand the root cause. What is the most important factor for humanity to conquer this epidemic disease Cancer ?

Dr. Tom Wu :
Cancer is usually caused by a bad lifestyle. Smoking, drinking, going to bed at a late hour, not getting enough exercise, living in a stressful environment, and above all else - eating the wrong foods. All of these things add to the risk factors for cancer.

In my medical practice people come from all over the world to see me for cancer. I tell them I don’t “treat” any kind of Cancer. I don’t treat any kind of disease. I only change the food they eat. It depends on what kind of cancer to say what kind of foods will work. They need to blend certain foods to break open the phytochemicals in the fiber of fruits and veggies. Then I will also give them Qigong and Breathing exercises to help relive the stress. Cancer is also an emotional disease. So the Qigong really helps. Conventional treatment uses 3 invasive methods, which are surgery, radiation, and drugs. These often damage the body so much that the patient suffers beyond repair, but I never advise the patient to refuse western medicine. It is a personal choice. In my practice often times a special high dose of Phytochemicals, from natural foods, can often relive the problem. Lets take breast cancer for instance. Usually if you supply the body with enough phytochemicals that contain Indole-3-Carbinol (I3C), which is plentiful in the cabbage, broccoli, cauliflower, & spinach the body will take this and fight the cancer. It is a fierce fighter of breast cancer. If they eat this food everyday as much as they can in a semi-raw state of 108 degrees Fahrenheit, it will be a fierce fighter against the cancer. This temperature will increase the absorption and can be achieved by blending the ingredients in a high powered blender. Most important is to use a high powered, 3 horse power blender, to break out the phytochemicals which are binded to the fibers. This abundance of phytochemicals allows the blood to be cleansed and stimulate the enzyme phase 2 inside each cell. A detoxification enzyme inside each cell, which is called enzyme phase 2. These enzymes need phytochemicals to stimulate their function. Most of the time the diet we eat of cooked and refined foods does not possess them... and for this reason the immune system does not function well. That’s the main reason why people get cancer.

Our dietary methods of guiding patients with cancer has been successful in a signifigant number of cases. The patient goes on a specialized smoothie diet with various vegetables, fruits and their accompanying seeds, and common garden herbs which are known to be rich in phytochemicals. It all gets thrown in the blender. The type of cancer the person has will dictate which foods are chosen.

Jeff :
Food cures have been known about since the time of Hippocrates. How can a simple household food reverse an epidemic like Children’s Autism ? Also please talk about what foods will actually stabilize blood sugar naturally for people who were born with Type 1 Diabetes ?

Dr. Tom Wu :
To heal the body we need to eat a variety of foods. Not just one. We need every variety, because each food has nutrients that other foods do not have. For example, people that have Autism, and this one is easy to prevent. Many times... Autism is caused by vaccinations or flu shots, which contain mercury. When these old age people get the flu shot they also get the mercury. Surely this mercury can cause Autism and cause Alzheimer’s disease too. But in the food Cilantro, lies the solution. The Chinese use Cilantro as a chelating agent to help bring out the Mercury from the body and take care for the problem. But it’s not only the Cilantro that is needed, you need to have a total lifestyle change and a high powered blender to extract all the phytochemicals from the vegetables.

For Type 1 Diabetes, I will use Swiss chard. It is also called red chard and green chard. These are very common vegetables. If people eat these kinds of vegetables everyday, they will improve their diabetes naturally. Swiss Chard and other specific vegetables contain a high amount of phytochemicals that are “Insulin-like”. With type 1 diabetes, the pancreas does not function, but you can use certain vegetables to regenerate the pancreas and help it secrete insulin again. You can also use certain Indian Herbs like Gymnema Sylvestre and Cumin seed, as these herbs can help rejuvenate the pancreas function to normal. If a high powered blender is used to make a smoothie including these foods then there is a good chance the Pancreas will eventually produce a normal supply of insulin and take care of type 1 naturally.

Type 2 diabetes it’s what we call a metabolic syndrome because it is usually accompanied by high blood pressure, overweight, insomnia, and cardiovascular disease. Sometimes it is called X-syndrome because it comes with so many problems. Type 2 diabetics have enough insulin, but it doesn’t work. This is called “insulin resistance”, and it too has a natural solution. What you have to do is add 3 or 4 cucumbers to the diet per day and then the insulin function will begin to improve. When the insulin function is restored, then the weight will naturally come down and the sugar will naturally come down.

Jeff :
Most people are shocked when you tell them you’re 67 years old. I’ve never seen anyone your age with such a radiant shine to their skin and no wrinkles. You have said that “Juicing” fruits and vegetables actually accelerates the aging process. Why does juicing not prevent, and what makes BLENDING the superior option for any nutrition program ?

Dr. Tom Wu :
That’s a good question. The juicer is excellent if you want more vitamins, minerals, and enzymes. But, this doesn’t prevent the body from getting older. To prevent aging and chronic disease we need the phytochemicals. When you use the juicer you do not get the anti-aging nutrients at all. Nearly all phytochemicals exist in the skin, fibers, and seeds. When you juice you throw these parts away. Some people use a blender which is less than 3 horsepower and the results have not been the same. A regular blender tastes good, but you don’t break out all the phytochemicals.

Jeff :
You also put the seeds in the blender right? Even the avocado seed !

Dr. Tom Wu :
Yes I do !. When I eat the avocado I always eat the seed. It is packed with very good nutrients. It has the life force. It is a very high Qi food ! It’s also the highest in soluble fiber. This soluble fiber binds to the fat and excess cholesterol. Then we can lower cholesterol and improve heart function naturally. We can improve the blood circulation by pulling out all the fatty deposits in our circulatory system with the soluble fiber of the avocado seed. Soluble fiber is very difficult to get in our diet. Oatmeal has some, but it cannot compare with the avocado seed. Any heart disease patient must eat the avocado including the seed.

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A New Approach to Treating Chronic Kidney Disease Replenishing Your Nephrons

As some of you may know, I have chronic kidney disease (CKD). Thanks to my wife and the scare put into me by my nephrologist, that I would soon have to begin dialysis, I have managed to get my CKD  in remission, or at least under control. My GFR number (that indicates when you must start dialysis) has held steady, or actually gotten better since my wife put me on a strict diet and I have lost about 15 pounds – and my nephrologist took me off of lisinopril (for blood pressure control), which seemed to raise my GFR by about three points. So, it appears I won’t have to go on dialysis any time soon.

All that being said, and with my strong interest in the use of stem cells and gene therapy in treating retinal diseases in ophthalmology, I have been searching the web for research on the use of stem cells to treat kidney disease or to produce new nephrons, the kidney cells that filter the blood as it passes through the kidney – and that go bad or die causing CKD. I think I have found very early research of that possibility.

Earlier this week, I saw a news  release from the University of Queensland in Australia that said that Dr. Melissa Little and her research group at the Institute of Molecular Bioscience (IMB) have found a set of six genes that can prompt some types of adult kidney cells to regress to an earlier stage of development (stem cells) and act like the precursors to the cells of the nephron. Since it is death or damage of nephrons that causes chronic kidney disease, by forcing adult cells to act like early nephrons, they may have potentially found a way to trigger the growth of new filters in the kidney.

All of your nephron cells are formed before birth and people with fewer nephrons are at higher risk of kidney disease.

Note: Dr. Little is one of sources that I had found in my web search as she had published a paper on “Stem Cell Options for Kidney Disease” in 2008, and we had corresponded at the beginning of this year when I began my search for a stem cell answer.

"This discovery is the first of its kind and offers hope to patients with chronic kidney disease. If we can find a way to provide new nephrons to an adult or increase nephron numbers in babies at birth, we could potentially reduce the risk of disease progression," said Professor Little.

This landmark paper, “Direct Transcriptional Reprogramming of Adult Cells to Embryonic Nephron Progenitors”, by Caroline E. Hendry, Jessica M. Vanslambrouck, Jessica Ineson, Norseha Suhaimi, Minoru Takasato, under the supervision of Professors Fiona Rae and Melissa H. Little, was published June 14th in the Journal of the American Society of Nephrology, the world's leading nephrology journal.

Professor Little said, “There was still more work to be done to encourage these reprogrammed early nephron cells to function and integrate. While this is a beginning, we hope it will inspire industry leaders and researchers around the world to invest further in cellular and bioengineering approaches to kidney repair and regeneration."

Stem Cells Australia Program Leader and Chair of Stem Cell Science at The University of Melbourne, Professor Martin Pera welcomed the research findings. "This innovative study provides evidence that adult cells can be reprogrammed to resemble the cells in the embryo that give rise to the kidney. The results pave the way for future studies that will enable researchers to produce human kidney cells in the laboratory, for use in studies of renal disorders, and for testing new drugs. Eventually this technology might help to make cells for transplantation to treat kidney disease," said Professor Pera.

The Technology

I have attempted to read Dr. Little’s paper on reprogramming kidney cells, and with her assistance, this is what I understand she and her colleagues have done, which is a very early step in the long road to someday being able to replenish nephron cells in an adult kidney.

In an earlier paper written by Caroline Hendry and Dr. Little, “Reprogramming the kidney: a novel approach for regeneration”, they discussed the various approaches that might be taken to re-create viable cells within a diseased kidney, including using  induced pluripotent stem cells (iPSCs) derived from skin cells or other sites, or even the use of embryonic stem cells (ESCs) that would be introduced into the kidney to form new nephrons (?), if they could – as shown in the accompanying figure (but how would you control the formation of the new cells?). But they concluded that the best approach would be reprogramming existing kidney cells to the progenitor stage, with the hope that these would develop into the needed new cells, or in this case, nephrons, the approach they ultimately used in this new research.

Figure1 | The application of reprogramming to the kidney, indicating the feasible starting cells and target phenotypes.

(i) Reprogramming may involve the directed differentiation of human embryonic stem cells (hESCs)/induced pluripotent stem cells (iPSCs) to a renal lineage. The iPSCs may be recipient-derived and may be derived from adult kidney cells or any other available adult cell type using the same factors. Directed differentiation is likely to recapitulate development; hence, it is likely to require differentiation through a nephron progenitor intermediate (induced nephron progenitor cell; iNP) but may continue on to more specific mature renal cell types.

(ii) A specific renal lineage may also be achieved via lineage-instructive reprogramming directly to that state from an adult cell type. Again, this may be the renal epithelium, renal stroma, or any other available differentiated adult cell type; however, this is likely to be more successful if the attractor states of the starting and target cell type are as close as possible. Reprogramming may be to the iNP state or directly to a more mature renal cell fate.

(iii) Finally, reprogramming may use the classical Yamanaka factors until the cells pass the point of no return, after which a renal lineage may be reached via the application of the appropriate environmental cues. Such cues may once again target the iNP state or aim to directly induce a more mature renal cell type.

As previously stated, the nephron progenitor population of the embryonic kidney gives rise to all of the nephron cells that will be present in the adult kidney, prior to birth. So, currently, what you’ve got at birth is what you live with.

Using a screening technique, the researchers were able to identify a group of six genes, that activate a network of genes that can reprogram adult proximal tubule cells back to the nephron progenitor stage – which in turn can form adult nephron cells. Although the researchers believe that other factors are required, they concluded that these results suggest that re-initiation of kidney development (nephron cells) from a population of adult cells (proximal tubule cells) by generating embryonic progenitors may be feasible, opening the way for additional cellular and bioengineering approaches to renal repair and regeneration.

In their literature search, they could not find any previous reports of kidney cells being reprogrammed back to a progenitor cell type. Their hope is that this discovery will lead others to follow their lead and begin further work in the possible reprogramming of adult kidney cells for the repair and rejuvenation of diseased kidneys.

Sources:

News Releases:

Research reprograms future of kidney health, Institute for Molecular Bioscience and Stem Cells Australia, June 14, 2013

Papers:

Direct Transcriptional Reprogramming of Adult Cells to Embryonic Nephron Progenitors, Hendry et al, Jnl Am Soc. Nephrology, June 11, 2013

Reprogramming the kidney: a novel approach for regeneration, Hendry and Little, Kidney International, March 21, 2012

Stem Cell Options for Kidney Disease, Hopkins et al, Jnl of Pathology, October 20, 2008


Resource:

Healthline.com recently launched a free, interactive "Human Body Maps" tool. One of the “maps” is of the kidney, showing and explaining how the kidney works to cleanse the body of waste material carried by the blood. To see a "map" of the kidney, and read how it functions, please follow this link.

Understanding The Use Of Bee Venom Therapy For Lyme Disease

By Jerry Long

Its a sickness coming from a bacterial infection from a tick bite. It goes through the whole body and can be infectious as well. It has the same symptoms when transmitted with other individuals getting this as well.

And for that one, a lot of medical contributions are happening right now. However, before going in deeply when it comes to bee venom therapy for lyme disease, its good to more about the illness first. This article explains some of its details.

Like other maladies, it has symptoms which any persons must take into account, whatever may the level of seriousness be. People who has this will experiencing chronic fatigue which can be more severe in the afternoon. They may lack endurance, dental infections wont quite heal, fibromyalgia, pain on joints, sensitivity on chemicals are just amongst others.

It is important for you to understand that you will have to undergo studies performed by your most trusted doctor in here. This is to see if you are well fit for the procedure and of course, it if its the right one for you and your problem. Well after the result, they are the ones that can determine if it best suit your condition.

There are herbs which can be used for this and by far recommended by most known physicians as of now. It may not fully cure the body but its really a way in prevent some of the symptoms anyone is experiencing. Its a more affordable solution as well because then. This can just be off from something which came from natural resources.

The cure for this situation comes from a substance and make it as a treatment for anyone who is diagnosed with such a case. It has a good volume of potent peptides and does a good deal in healing affected areas in the body. It also contains melittin which has been considered having a strong effects on it with small doses.

Many persons have claim most of the heavenly things they have gotten upon using this type of medication for their situations. It is know to to be separation from any medication procedures as one for their own cures. The cure came from raw materials and tested further to consider it as a form of remedy for you and anyone else.

But before dong anything else that concerns this type of process, people are still advice to have an appointment with their medical practitioner. This is a way to consider if there are things that needs to work out with the patient. Of course, its also a way in determining if he or she has any allergies on this solution.

The utilization of this particular technique is used by a good volume of individuals to cure for this kind of sickness. Its availability is in the industry right now and further studies for it are still happening right now. For those that want to have this, let doctors check it out first before even using it.

About the Author:

When you are looking for the facts about bee venom therapy for Lyme disease, come to our web pages online here today. Additional details are available at http://www.lyme-beevenom.com now.